Stadsbelang en standsbesef: Gezondheidszorg en medisch beroep in Groningen 1500–1730

perfused organs to examine sugar catabolism and metabolism, Holmes underscores the relationship between the laboratory elucidation of a significant intermediate compound like acetone and the clinical knowledge of ketone body production in diabetes. But, he concludes, the early-twentieth-century integrative optimism evaporated, to be re-formulated in the 1930s with the announcement of the "Embden-Meyerhof' pathway and the "Krebs" cycle the eponymous titles themselves pointing up the inherent difficulties in separating contributions to the field as a whole. However, by the middle of the twentieth century the "ongoing investigative stream" is much broader, and it moves more swiftly. Whilst the definition of a research field may remain as an analytical goal, its achievement becomes more difficult, and in assessing this period Holmes' "research field" contracts, two notable exclusions being A. V. Hill and Walter Morley Fletcher. But in a short book, such shortcomings can be excused. As he acknowledges finally, Holmes raises many questions, but provides few answers. This is no crime, as those questions are thoughtful, and thought-provoking. The book may suffer from its apparently narrow title, which hides a broad, sweeping account that can be widely recommended.